+44 (0) 1223 755950
+1 832 327 7413
E3 SUMO-Protein Ligase CBX4 (CBX4) Antibody
REQUEST MORE INFO
Catalogue No: abx031611
Price:
US$326.25
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
CBX4 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. CBX4 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells. It participates in maintaining the transcriptionally repressive state of genes. CBX4 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. CBX4 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.
Research Articles on E3 SUMO-Protein Ligase CBX4 (CBX4)
| Target | E3 SUMO-Protein Ligase CBX4 (CBX4) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 80-110 amino acids from the N-terminal region of human PC2 (CBX4). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O00257 (UniProt, ExPASy) |
| UniProt Secondary AC | B1PJR7, Q6TPI8, Q96C04 |
| UniProt Entry Name | CBX4_HUMAN |
| Gene Symbol | CBX4 |
| NCBI Accession | NP_003646.2 |
| KEGG | hsa:8535 |
| String | 9606.ENSP00000269397 |
| Molecular Weight | Calculated MW: 61.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |