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Platelet Derived Growth Factor Subunit B (PDGFB) Antibody
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Catalogue No: abx001108
Price:
US$203.00
(Size: 20 µl)
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PDGFB Antibody is a Rabbit Polyclonal antibody against PDGFB. The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Research Articles on Platelet Derived Growth Factor Subunit B (PDGFB)
| Target | Platelet Derived Growth Factor Subunit B (PDGFB) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 140-241 of human PDGFB. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P01127 (UniProt, ExPASy) |
| UniProt Secondary AC | G3XAG8, P78431, Q15354, Q6FHE7, Q9UF23 |
| UniProt Entry Name | PDGFB_HUMAN |
| Gene Symbol | PDGFB |
| GeneID | 5155 |
| NCBI Accession | NP_002599.1 |
| KEGG | hsa:5155 |
| String | 9606.ENSP00000330382 |
| Molecular Weight | Calculated MW: 27 kDa Observed MW: 27 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |