Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Antibody

Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1) Antibody is a Rabbit Polyclonal antibody for the detection of PDK1.

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Target	Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	pyruvate dehydrogenase kinase, isozyme 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q15118 (UniProt, ExPASy)
UniProt Secondary AC	B2R6T1, B7Z937, D3DPD8, E9PD65, Q308M4
UniProt Entry Name	PDK1_HUMAN
Gene Symbol	PDK1
GeneID	5163
OMIM	602524
HGNC	8809
KEGG	hsa:5163
Ensembl	ENSG00000152256
String	9606.ENSP00000376352
Molecular Weight	Observed MW: 50 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue