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PDPK1 (pS396) Antibody
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Catalogue No: abx031991
Price:
US$326.25
(Size: 80 µl)
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PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3, 4, 5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Research Articles on PDPK1 (pS396)
| Target | PDPK1 (pS396) |
| Clonality | Polyclonal |
| Target Modification | Ser396 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S396 of human PDPK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O15530 (UniProt, ExPASy) |
| UniProt Secondary AC | H0Y4Z0, Q59EH6, Q6FI20, Q8IV52, Q9BRD5 |
| UniProt Entry Name | PDPK1_HUMAN |
| KEGG | hsa:5170 |
| String | 9606.ENSP00000344220 |
| Molecular Weight | Calculated MW: 63.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |