Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3 (PDZK1) Antibody

PDZK1 Antibody is a Rabbit Polyclonal antibody against PDZK1. This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Target	Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3 (PDZK1)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PDZK1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q5T2W1 (UniProt, ExPASy)
UniProt Secondary AC	B4DPB9, E7EU02, O60450, Q5T5P6, Q9BQ41
UniProt Entry Name	NHRF3_HUMAN
Gene Symbol	PDZK1
GeneID	5174
NCBI Accession	NP_001188254.1
KEGG	hsa:5174
String	9606.ENSP00000394485
Molecular Weight	Calculated MW: 57 kDa Observed MW: 67 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3 (PDZK1)

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