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Peroxisomal Biogenesis Factor 5 (PEX5) Antibody
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Catalogue No: abx004428
Price:
US$217.50
(Size: 20 µl)
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PEX5 Antibody is a Rabbit Polyclonal antibody against PEX5. The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
Research Articles on Peroxisomal Biogenesis Factor 5 (PEX5)
| Target | Peroxisomal Biogenesis Factor 5 (PEX5) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PEX5. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P50542 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K891, B4DZ45, B7ZAD5, D3DUT8, Q15115, Q15266, Q96FN7 |
| UniProt Entry Name | PEX5_HUMAN |
| Gene Symbol | PEX5 |
| GeneID | 5830 |
| NCBI Accession | NP_000310.2 |
| KEGG | hsa:5830 |
| String | 9606.ENSP00000391601 |
| Molecular Weight | Calculated MW: 71 kDa Observed MW: 70-85 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |