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Profilin-1 (PFN1) Antibody
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Catalogue No: abx001078
Price:
US$203.00
(Size: 20 µl)
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PFN1 Antibody is a Rabbit Polyclonal antibody against PFN1. The dynamic polymerization and depolymerization of actin filaments, a process governed by external and internal signaling events, is vital for cell motility (immune cell function, migration, invasion, metastasis, angiogenesis), cell division and adhesion. Among the many regulators of actin dynamics are profilins. Profilins are conserved actin binding proteins that affect the rate of actin polymerization by binding actin monomers and promoting the exchange of ADP for ATP (reviewed in 1). Profilins bind to proteins involved in the regulation of actin dynamics including palladin (2), dynamin-1 (3), VASP (4) and N-WASP (5). In mice, knockout of the ubiquitously expressed profilin-1 indicates that the protein is essential for embryonic development (6). Profilin-2 is primarily expressed in brain and functions in the regulation of neurite outgrowth (7), membrane trafficking and endocytosis (3). The recently cloned profilin-3 is expressed in kidney and testes (8).
Research Articles on Profilin-1 (PFN1)
| Target | Profilin-1 (PFN1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat, Monkey |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human Profilin1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P07737 (UniProt, ExPASy) |
| UniProt Secondary AC | Q53Y44 |
| UniProt Entry Name | PROF1_HUMAN |
| Gene Symbol | PFN1 |
| GeneID | 5216 |
| NCBI Accession | NP_005013.1 |
| KEGG | hsa:5216 |
| String | 9606.ENSP00000225655 |
| Molecular Weight | Calculated MW: 15 kDa Observed MW: 13 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |