Signal Transducer And Activator of Transcription 1 Phospho-Tyr701 (STAT1 pY701) Antibody

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Catalogue No: abx011828
Price: US$406.00
(Size: 100 µg)

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Datasheet SDS
Signal Transducer And Activator of Transcription 1 Phospho-Tyr701 (STAT1 pY701) Antibody is a Rabbit Polyclonal antibody for the detection of Phospho-STAT1 (Tyr701).

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

Target Signal Transducer And Activator of Transcription 1 Phospho-Tyr701 (STAT1 pY701)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A phospho specific peptide corresponding to residues surrounding Y701 of human STAT1
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC P42224 (UniProt, ExPASy)
Gene Symbol STAT1
GeneID 6772
OMIM 600555
HGNC 11362
Ensembl ENSG00000115415
Molecular Weight Observed MW: 80-90 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note This product is for research use only.
Research Articles on Signal Transducer And Activator of Transcription 1 Phospho-Tyr701 (STAT1 pY701)


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