Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PI3KC3) Antibody

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Catalogue No: abx033820
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.

Target Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PI3KC3)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human PI3KC3.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q8NEB9 (UniProt, ExPASy)
UniProt Secondary AC Q15134
UniProt Entry Name PK3C3_HUMAN
NCBI Accession NP_002638.2
KEGG hsa:5289
String 9606.ENSP00000262039
Molecular Weight Calculated MW: 102 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse, Rat, Pig and Xenopus PIK3C3.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PI3KC3)


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