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Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PI3KC3) Antibody
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Catalogue No: abx033820
Price:
US$326.25
(Size: 80 µl)
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PI3KC3 is a catalytic subunit of the PI3K complex involved in the transport of lysosomal enzyme precursors to lysosomes. This enzyme acts catalytically to convert 1-phosphatidyl-1D-myo-inositol to 1-phosphatidyl-1D-myo-inositol 3-phosphate. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway.
Research Articles on Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PI3KC3)
| Target | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PI3KC3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human PI3KC3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8NEB9 (UniProt, ExPASy) |
| UniProt Secondary AC | Q15134 |
| UniProt Entry Name | PK3C3_HUMAN |
| NCBI Accession | NP_002638.2 |
| KEGG | hsa:5289 |
| String | 9606.ENSP00000262039 |
| Molecular Weight | Calculated MW: 102 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Pig and Xenopus PIK3C3. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |