Phosphatidylinositol Glycan Anchor Biosynthesis Class A (PIGA) Antibody

This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

Target	Phosphatidylinositol Glycan Anchor Biosynthesis Class A (PIGA)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 455-484 amino acids from the C-terminal region of human PIGA.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P37287 (UniProt, ExPASy)
UniProt Secondary AC	B4E0V2, Q16025, Q16250
UniProt Entry Name	PIGA_HUMAN
Gene Symbol	PIGA
KEGG	hsa:5277
String	9606.ENSP00000369820
Molecular Weight	Calculated MW: 54.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Phosphatidylinositol Glycan Anchor Biosynthesis Class A (PIGA)

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