Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma (PIK3R3) Antibody

PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. It is a component of a heterodimer of p110 (catalytic) and p55 (regulatory) subunits. The protein is expressed at highest levels in brain and testis. Lower levels are detected in adipose tissue, kidney, heart, lung and skeletal muscle. The protein contains 2 SH2 domains.

Target	Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma (PIK3R3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 316-346 amino acids from the C-terminal region of human PIK3R3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92569 (UniProt, ExPASy)
UniProt Secondary AC	B2R9C1, D3DQ12, O60482, Q5T4P1, Q5T4P2
UniProt Entry Name	P55G_HUMAN
NCBI Accession	NP_001107644.1 NP_003620.3
KEGG	hsa:8503
String	9606.ENSP00000262741
Molecular Weight	Calculated MW: 54.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Phosphatidylinositol 3-Kinase Regulatory Subunit Gamma (PIK3R3)

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