Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1) Antibody

Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.

Target	Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1)
Clonality	Monoclonal
Reactivity	Human, Mouse, Rat, Monkey
Tested Applications	ELISA, WB, IHC
Host	Mouse
Recommended dilutions	WB: 1/1000, IHC-P: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified His-tagged Human PIN1 protein
Isotype	IgG1
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13526 (UniProt, ExPASy)
UniProt Secondary AC	A8K4V9, Q53X75
NCBI Accession	NP_006212.1
Molecular Weight	Calculated MW: 18.2 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Reacts with Human, Mouse, Rat and African Green Monkey PIN1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 1 (PIN1)

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