Particularly Interesting New Cys-His Protein 1 (PINCH) Antibody

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading.

Target	Particularly Interesting New Cys-His Protein 1 (PINCH)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human PINCH expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P48059 (UniProt, ExPASy)
UniProt Secondary AC	B2RAJ4, B7Z483, B7Z7R3, B7Z907, Q53TE0, Q9BS44
UniProt Entry Name	LIMS1_HUMAN
Gene Symbol	LIMS1
GeneID	3987
OMIM	602567
HGNC	6616
KEGG	hsa:3987
Ensembl	ENSG00000169756
String	9606.ENSP00000446121
Molecular Weight	37 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Particularly Interesting New Cys-His Protein 1 (PINCH)

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