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PDZ Protein Interacting Specifically With TC10 (PIST) Antibody
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Catalogue No: abx033276
Price:
US$326.25
(Size: 80 µl)
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PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner. PIST, a PDZ domain-containing Golgi protein, was discovered in a yeast two-hybrid system as a binding partner to Beclin-1, a Bcl-2-interacting protein homologous to the yeast autophagy gene apg6. Experiments with mutant PIST proteins lacking the PDZ domain showed that PIST interaction with Beclin-1 through its coiled-coil domain can modulate Beclin-1 activity and suggest that PIST interactions with other proteins through its PDZ domain may regulate the activity of PIST and Beclin-1.
Research Articles on PDZ Protein Interacting Specifically With TC10 (PIST)
| Target | PDZ Protein Interacting Specifically With TC10 (PIST) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 164-193 amino acids from the Central region of human PIST. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9HD26 (UniProt, ExPASy) |
| UniProt Secondary AC | A6NM30, Q59FS4, Q969U8 |
| UniProt Entry Name | GOPC_HUMAN |
| String | 9606.ENSP00000357484 |
| Molecular Weight | Calculated MW: 50.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse GOPC. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |