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Protein Kinase C Nu Type (PKC nu) Antibody
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Catalogue No: abx033122
Price:
US$326.25
(Size: 80 µl)
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Protein kinase C (PKC) is a family of serine and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC nu is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
Research Articles on Protein Kinase C Nu Type (PKC nu)
| Target | Protein Kinase C Nu Type (PKC nu) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 352-384 amino acids from human PKC-nu. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O94806 (UniProt, ExPASy) |
| UniProt Secondary AC | D6W587, Q53TR7, Q8NEL8 |
| UniProt Entry Name | KPCD3_HUMAN |
| NCBI Accession | NP_005804.1 |
| KEGG | hsa:23683 |
| String | 9606.ENSP00000368356 |
| Molecular Weight | Calculated MW: 100 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |