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Protein Kinase C Alpha Type (PRKCA) Antibody
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Catalogue No: abx011394
Price:
US$406.00
(Size: 100 µg)
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Protein Kinase C Alpha Type (PRKCA) Antibody is a Rabbit Polyclonal antibody for the detection of KPCA. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca (2+) handling in myocytes.
Research Articles on Protein Kinase C Alpha Type (PRKCA)
| Target | Protein Kinase C Alpha Type (PRKCA) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | protein kinase C, alpha |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P17252 (UniProt, ExPASy) |
| UniProt Secondary AC | B5BU22, Q15137, Q32M72, Q96RE4 |
| UniProt Entry Name | KPCA_HUMAN |
| Gene Symbol | PRKCA |
| GeneID | 5578 |
| OMIM | 176960 |
| HGNC | 9393 |
| KEGG | hsa:5578 |
| Ensembl | ENSG00000154229 |
| String | 9606.ENSP00000408695 |
| Molecular Weight | Observed MW: 77 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |