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Cytosolic Phospholipase A2 (PLA2G4A) Antibody
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Catalogue No: abx033974
Price:
US$326.25
(Size: 80 µl)
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PLA2G4A is a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca (2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Research Articles on Cytosolic Phospholipase A2 (PLA2G4A)
| Target | Cytosolic Phospholipase A2 (PLA2G4A) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 513-541 amino acids from the Central region of human PLA2G4A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P47712 (UniProt, ExPASy) |
| UniProt Secondary AC | B1AKG4, Q29R80 |
| UniProt Entry Name | PA24A_HUMAN |
| KEGG | hsa:5321 |
| String | 9606.ENSP00000356436 |
| Molecular Weight | Calculated MW: 85.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Chicken and Zebrafish PLA2G4A. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |