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Tissue-Type Plasminogen Activator (PLAT) Antibody
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Catalogue No: abx004325
Price:
US$217.50
(Size: 20 µl)
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PLAT Antibody is a Rabbit Polyclonal antibody against PLAT. This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Research Articles on Tissue-Type Plasminogen Activator (PLAT)
| Target | Tissue-Type Plasminogen Activator (PLAT) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 23-320 of human tPA/tPA/PLAT. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P00750 (UniProt, ExPASy) |
| UniProt Entry Name | TPA_HUMAN |
| Gene Symbol | PLAT |
| GeneID | 5327 |
| NCBI Accession | NP_000921.1 |
| KEGG | hsa:5327 |
| String | 9606.ENSP00000220809 |
| Molecular Weight | Calculated MW: 63 kDa Observed MW: 63 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |