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Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) Antibody
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Catalogue No: abx001219
Price:
US$203.00
(Size: 20 µl)
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PLAUR Antibody is a Rabbit Polyclonal antibody against PLAUR. Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559).
Research Articles on Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR)
| Target | Urokinase Plasminogen Activator Surface Receptor / uPAR / CD87 (PLAUR) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q03405 (UniProt, ExPASy) |
| Gene Symbol | PLAUR |
| GeneID | 5329 |
| NCBI Accession | NP_002650.1 |
| Molecular Weight | Calculated MW: 37 kDa Observed MW: 36-72 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |