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Promyelocytic Leukemia Protein (PML) Antibody
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Catalogue No: abx001098
Price:
US$232.00
(Size: 20 µl)
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PML Antibody is a Rabbit Polyclonal antibody against PML. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Research Articles on Promyelocytic Leukemia Protein (PML)
| Target | Promyelocytic Leukemia Protein (PML) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human PML. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P29590 (UniProt, ExPASy) |
| UniProt Entry Name | PML_HUMAN |
| Gene Symbol | PML |
| GeneID | 5371 |
| NCBI Accession | NP_150241.2 |
| KEGG | hsa:5371 |
| String | 9606.ENSP00000268058 |
| Molecular Weight | Calculated MW: 98 kDa Observed MW: 70-130 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |