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Purine Nucleoside Phosphorylase (PNP) Antibody
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Catalogue No: abx004426
Price:
US$203.00
(Size: 20 µl)
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PNP Antibody is a Rabbit Polyclonal antibody against PNP. This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Research Articles on Purine Nucleoside Phosphorylase (PNP)
| Target | Purine Nucleoside Phosphorylase (PNP) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IP: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-289 of human PNP. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P00491 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R8S5, D3DS00, Q15160, Q5PZ03 |
| UniProt Entry Name | PNPH_HUMAN |
| Gene Symbol | PNP |
| GeneID | 4860 |
| NCBI Accession | NP_000261.2 |
| KEGG | hsa:4860 |
| String | 9606.ENSP00000354532 |
| Molecular Weight | Calculated MW: 32 kDa Observed MW: 30 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |