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DNA Polymerase Eta (POLH) Antibody
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Catalogue No: abx001515
Price:
US$348.00
(Size: 60 µl)
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POLH Antibody is a Rabbit Polyclonal antibody against POLH. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].
Research Articles on DNA Polymerase Eta (POLH)
| Target | DNA Polymerase Eta (POLH) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human DNA polymerase eta |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y253 (UniProt, ExPASy) |
| UniProt Secondary AC | Q7L8E3, Q96BC4, Q9BX13 |
| UniProt Entry Name | POLH_HUMAN |
| Gene Symbol | POLH |
| GeneID | 5429 |
| NCBI Accession | NP_006493.1 |
| String | 9606.ENSP00000361310 |
| Molecular Weight | Calculated MW: 46 kDa/78 kDa Observed MW: 70 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |