DNA Polymerase Iota (POLI) Antibody

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Catalogue No: abx028115
Price: US$326.25
(Size: 80 µl)

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DNA Polymerase Iota (POLI) Antibody
DNA Polymerase Iota (POLI) Antibody DNA Polymerase Iota (POLI) Antibody

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Datasheet SDS
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Target DNA Polymerase Iota (POLI)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 673-701 amino acids from the C-terminal region of human POLI.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9UNA4 (UniProt, ExPASy)
UniProt Secondary AC Q8N590, Q9H0S1, Q9NYH6
UniProt Entry Name POLI_HUMAN
Gene Symbol POLI
String 9606.ENSP00000462664
Molecular Weight Calculated MW: 83 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on DNA Polymerase Iota (POLI)
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