+44 (0) 1223 755950
+1 832 327 7413
Poly ADP-Ribose Polymerase 1 (PARP1) Antibody
REQUEST MORE INFO
Catalogue No: abx239938
Price:
US$406.00
(Size: 100 µg)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
Poly ADP-Ribose Polymerase 1 (PARP1) Antibody is a Mouse Monoclonal antibody for the detection of PARP1. PARP1 (poly (ADP-ribose) polymerase 1) is a nuclear enzyme catalyzing the poly (ADP-ribosyl) ation of many key proteins in vivo. The normal function of PARP1 is the routine repair of DNA damage. Activated by DNA strand breaks, the PARP1 is cleaved into an 85 to 89-kDa COOH-terminal fragment and a 24-kDa NH2-terminal peptide by caspases during the apoptotic process. The appearance of PARP fragments is commonly considered as an important biomarker of apoptosis.
Research Articles on Poly ADP-Ribose Polymerase 1 (PARP1)
| Target | Poly ADP-Ribose Polymerase 1 (PARP1) |
| Clonality | Monoclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Mouse |
| Recommended dilutions | WB: 1/5000 - 1/30000, IHC: 1/100 - 1/1000, IF/ICC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | poly (ADP-ribose) polymerase 1 |
| Isotype | IgG1 |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P09874 (UniProt, ExPASy) |
| UniProt Secondary AC | B1ANJ4, Q8IUZ9 |
| UniProt Entry Name | PARP1_HUMAN |
| Gene Symbol | PARP1 |
| GeneID | 142 |
| OMIM | 173870 |
| HGNC | 270 |
| KEGG | hsa:142 |
| Ensembl | ENSG00000143799 |
| String | 9606.ENSP00000355759 |
| Molecular Weight | Observed MW: 115 kDa, 89 kDa |
| Buffer | 0.01 M PBS, pH 7.4. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |