Peroxisome Proliferator Activated Receptor Delta (PPARD) Antibody

PPARD Antibody is a Rabbit Polyclonal antibody against PPARD. This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.

Target	Peroxisome Proliferator Activated Receptor Delta (PPARD)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fragment corresponding to 19-90aa of human PPARD.
Isotype	IgG
Form	Lyophilized
Purification	Purified by Protein A/G column chromatography.
Reconstitution	Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
Molecular Weight	Observed MW: 46 kDa
Buffer	Prior to lyophilization: 0.02% NaN3.
Specificity	Predicted to react with Mouse and Rat PPARD.
Concentration	Lyophilized form: Not applicable. After reconstitution: 1 mg/ml.
Availability	Shipped within 7-15 working days.
Note	This product is for research use only.

Research Articles on Peroxisome Proliferator Activated Receptor Delta (PPARD)

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