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Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) Antibody
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Catalogue No: abx011791
Price:
US$420.50
(Size: 100 µl)
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The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A)
| Target | Protein Phosphatase, Mg2+/Mn2+ Dependent 1A (PPM1A) |
| Clonality | Monoclonal |
| Reactivity | Human, Monkey |
| Tested Applications | ELISA, WB, FCM |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Purified from ascites by Protein G chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P35813 (UniProt, ExPASy) |
| UniProt Secondary AC | B5BU11, J3KNM0, O75551 |
| GeneID | 5494 |
| Molecular Weight | 42.4 kDa |
| Buffer | PBS, containing 0.05% sodium azide. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |