Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody

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Catalogue No: abx027662
Price: US$326.25
(Size: 80 µl)

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Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody

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Datasheet SDS
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Target Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O15297 (UniProt, ExPASy)
UniProt Secondary AC Q53XP4, Q6P991, Q8IVR6
UniProt Entry Name PPM1D_HUMAN
Gene Symbol PPM1D
KEGG hsa:8493
String 9606.ENSP00000306682
Molecular Weight Calculated MW: 66.7 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse PPM1D.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D)