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Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody
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Catalogue No: abx033955
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D)
| Target | Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 571-602 amino acids from the C-terminal region of human PPM1D. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O15297 (UniProt, ExPASy) |
| UniProt Secondary AC | Q53XP4, Q6P991, Q8IVR6 |
| UniProt Entry Name | PPM1D_HUMAN |
| Gene Symbol | PPM1D |
| NCBI Accession | NP_003611.1 |
| KEGG | hsa:8493 |
| String | 9606.ENSP00000306682 |
| Molecular Weight | Calculated MW: 66.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
