Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F) Antibody

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Target	Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49593 (UniProt, ExPASy)
UniProt Secondary AC	A8K6G3, B7Z2C3, Q96PM2
UniProt Entry Name	PPM1F_HUMAN
KEGG	hsa:9647
String	9606.ENSP00000263212
Molecular Weight	Calculated MW: 49.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F)

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