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Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F) Antibody
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Catalogue No: abx033963
Price:
US$326.25
(Size: 80 µl)
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PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis.
Research Articles on Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F)
| Target | Protein Phosphatase, Mg2+/Mn2+ Dependent 1F (PPM1F) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 409-439 amino acids from the C-terminal region of human PPM1F. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P49593 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K6G3, B7Z2C3, Q96PM2 |
| UniProt Entry Name | PPM1F_HUMAN |
| KEGG | hsa:9647 |
| String | 9606.ENSP00000263212 |
| Molecular Weight | Calculated MW: 49.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |