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Melanoma Antigen Preferentially Expressed In Tumors (PRAME) Antibody
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Catalogue No: abx004948
Price:
US$217.50
(Size: 20 µl)
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PRAME Antibody is a Rabbit Polyclonal antibody against PRAME. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
Research Articles on Melanoma Antigen Preferentially Expressed In Tumors (PRAME)
| Target | Melanoma Antigen Preferentially Expressed In Tumors (PRAME) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PRAME. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P78395 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6Y7, O43481, Q8IXN8 |
| UniProt Entry Name | PRAME_HUMAN |
| Gene Symbol | PRAME |
| GeneID | 23532 |
| OMIM | 606021 |
| NCBI Accession | NP_006106.1 |
| HGNC | 9336 |
| KEGG | hsa:23532 |
| Ensembl | ENSG00000185686 |
| String | 9606.ENSP00000445675 |
| Molecular Weight | Calculated MW: 58 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |