PR Domain Zinc Finger Protein 2 (PRDM2) Antibody

PRDM2 is a 250-kD nuclear protein containing 8 zinc finger motifs. It contains an RB-binding motif that is related to that of the adenovirus E1A oncoprotein; RIZ also shares an antigenic epitope with the C terminus of E1A. It is expressed in human retinoblastoma cells and at low levels in all other human cell lines examined. Using fluorescence in situ hybridization, the PRDM2 gene has been mapped to 1p36. PRDM2 may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, skin, and lymphoid tumors.

Target	PR Domain Zinc Finger Protein 2 (PRDM2)
Clonality	Polyclonal
Reactivity	Rat
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC-P: 1/100 - 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant GST fusion protein encoding 245-573 AA of rat Riz1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13029 (UniProt, ExPASy)
UniProt Secondary AC	B1AJZ4, B5MC68, Q13149, Q14550, Q5THJ1, Q5VUL9
UniProt Entry Name	PRDM2_HUMAN
NCBI Accession	NP_001007258.1 NP_001129082.1 NP_036363.2 NP_056950.2
KEGG	hsa:7799
String	9606.ENSP00000235372
Molecular Weight	Calculated MW: 188 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	This antibody also recognises the isoform beta (Riz2) of PRDM2 (185 kDa).
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on PR Domain Zinc Finger Protein 2 (PRDM2)

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