Perforin 1 (PRF1) Antibody

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Catalogue No: abx000550
Price: US$348.00
(Size: 60 µl)
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Western blot analysis of extracts of various cell lines using Perforin Antibody (1/1000 dilution).
Perforin 1 (PRF1) Antibody Perforin 1 (PRF1) Antibody Perforin 1 (PRF1) Antibody Perforin 1 (PRF1) Antibody

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Datasheet SDS
PRF1 Antibody is a Rabbit Polyclonal antibody against PRF1. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

Target Perforin 1 (PRF1)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein corresponding to human Perforin
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P14222 (UniProt, ExPASy)
UniProt Secondary AC B2R6X4, Q59F57, Q86WX7
UniProt Entry Name PERF_HUMAN
Gene Symbol PRF1
GeneID 5551
OMIM 170280
NCBI Accession NP_001076585.1
HGNC 9360
KEGG hsa:5551
Ensembl ENSG00000180644
String 9606.ENSP00000398568
Molecular Weight Calculated MW: 61 kDa
Observed MW: 70 kDa
Buffer PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration 1 mg/ml
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Perforin 1 (PRF1)


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