5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2) Antibody

This product is currently in development. The lead time for this product may be several months. Please contact us at [email protected] for an updated lead time before purchasing this product.

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. This antibody is supplied as crude ascites.

Target	5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Human PRKAA2 recombinant protein.
Isotype	IgG2a Kappa
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P54646 (UniProt, ExPASy)
UniProt Secondary AC	Q9H1E8, Q9UD43
UniProt Entry Name	AAPK2_HUMAN
KEGG	hsa:5563
String	9606.ENSP00000360290
Molecular Weight	Calculated MW: 62.3 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Please enquire.
Note	This product is for research use only.

Research Articles on 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2)

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