+44 (0) 1223 755950
+1 832 327 7413
5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2) Antibody
REQUEST MORE INFO
Catalogue No: abx025944
Price:
US$290.00
(Size: 80 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Research Articles on 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2)
| Target | 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 145-173 amino acids from the Central region of human PRKAA2 (Thr172). |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P54646 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9H1E8, Q9UD43 |
| UniProt Entry Name | AAPK2_HUMAN |
| KEGG | hsa:5563 |
| String | 9606.ENSP00000360290 |
| Molecular Weight | Calculated MW: 62.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Pig PRKAA2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |