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Protein Kinase, AMP Activated Beta 2 (PRKAB2) Antibody
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Catalogue No: abx005275
Price:
US$203.00
(Size: 20 µl)
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PRKAB2 Antibody is a Rabbit Polyclonal antibody against PRKAB2. The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene.
Research Articles on Protein Kinase, AMP Activated Beta 2 (PRKAB2)
| Target | Protein Kinase, AMP Activated Beta 2 (PRKAB2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human PRKAB2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O43741 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K9V5, B4DH06, Q5VXY0 |
| UniProt Entry Name | AAKB2_HUMAN |
| Gene Symbol | PRKAB2 |
| GeneID | 5565 |
| NCBI Accession | NP_005390.1 |
| KEGG | hsa:5565 |
| String | 9606.ENSP00000254101 |
| Molecular Weight | Calculated MW: 30 kDa Observed MW: 33 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |