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5'-AMP-Activated Protein Kinase Subunit Gamma-3 (PRKAG3) Antibody
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Catalogue No: abx033146
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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PRKAG3 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.
Research Articles on 5'-AMP-Activated Protein Kinase Subunit Gamma-3 (PRKAG3)
| Target | 5'-AMP-Activated Protein Kinase Subunit Gamma-3 (PRKAG3) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 148-178 amino acids from the Central region of human PRKAG3. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9UGI9 (UniProt, ExPASy) |
| UniProt Secondary AC | Q4QQG8, Q4V779, Q9NRL1 |
| UniProt Entry Name | AAKG3_HUMAN |
| Gene Symbol | PRKAG3 |
| GeneID | 53632 |
| OMIM | 604976 |
| NCBI Accession | NP_059127.2 |
| KEGG | hsa:53632 |
| String | 9606.ENSP00000397133 |
| Molecular Weight | Calculated MW: 54.3 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
