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Protein Kinase, CGMP Dependent Type I (PRKG1) Antibody
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Catalogue No: abx002002
Price:
US$217.50
(Size: 20 µl)
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PRKG1 Antibody is a Rabbit Polyclonal antibody against PRKG1. Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
Research Articles on Protein Kinase, CGMP Dependent Type I (PRKG1)
| Target | Protein Kinase, CGMP Dependent Type I (PRKG1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRKG1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13976 (UniProt, ExPASy) |
| UniProt Secondary AC | A5YM56, B3KSF3, E2PU10, P14619, Q5JP05, Q5JSJ6, Q6P5T7 |
| Gene Symbol | PRKG1 |
| GeneID | 5592 |
| NCBI Accession | NP_006249.1 |
| Molecular Weight | Calculated MW: 76 kDa Observed MW: 65 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1.85 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |