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Human 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) Protein
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Catalogue No: abx168101
Price:
US$246.50
(Size: 10 µg)
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Proteasome 26S Subunit, Non ATPase 4 Protein is a recombinant Human protein expressed in E. coli. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)
| Target | 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) |
| Origin | Human |
| Expression | Recombinant |
| Tested Applications | WB, SDS-PAGE |
| Host | E. coli |
| Conjugation | Unconjugated |
| Form | Lyophilized |
| Purity | > 95% |
| Reconstitution | To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P55036 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DV16, Q5VWC5, Q9NS92 |
| UniProt Entry Name | PSMD4_HUMAN |
| Gene Symbol | PSMD4 |
| GeneID | 5710 |
| OMIM | 601648 |
| NCBI Accession | NP_002801.1 NM_002810.2 |
| HGNC | 9561 |
| KEGG | hsa:5710 |
| Ensembl | ENSG00000159352 |
| String | 9606.ENSP00000357879 |
| Molecular Weight | Calculated MW: 70.7 kDa |
| Sequence Fragment | Met1-Lys377 |
| Tag | N-terminal His tag and GST tag |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Activity | Not tested |
| Concentration | Prior to lyophilization: 200 µg/ml |
| Availability | Shipped within 5-7 working days. |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |