Human Proteasome Subunit Beta Type 1 (PSMB1) Protein

Proteasome Subunit Beta Type 1 (PSMB1) is a recombinant enzyme. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species.

Target	Proteasome Subunit Beta Type 1 (PSMB1)
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	E. coli
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Purity	> 95% (SDS-PAGE)
Storage	Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P20618 (UniProt, ExPASy)
UniProt Secondary AC	B5BU76, Q9BWA8
UniProt Entry Name	PSB1_HUMAN
Gene Symbol	PSMB1
GeneID	5689
OMIM	602017
HGNC	9537
KEGG	hsa:5689
Ensembl	ENSG00000008018
String	9606.ENSP00000262193
Sequence	MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMFS PYVFNGGTIL AIAGEDFAIV ASDTRLSEGF SIHTRDSPKC YKLTDKTVIG CSGFHGDCLT LTKIIEARLK MYKHSNNKAM TTGAIAAMLS TILYSRRFFP YYVYNIIGGL DEEGKGAVYS FDPVGSYQRD SFKAGGSASA MLQPLLDNQV GFKNMQNVEH VPLSLDRAMR LVKDVFISAA ERDVYTGDAL RICIVTKEGI REETVSLRKD.
Activity	Not tested
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on Proteasome Subunit Beta Type 1 (PSMB1)

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