Human Proteasome Subunit Beta Type 3 (PSMB3) Protein

Proteasome Subunit Beta Type 3 (PSMB3) is a recombinant enzyme. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. The 26 S proteasome may be involved in trinucleotide repeat expansion, a phenomenon which is associated with many hereditary neurological diseases. Pseudogenes have been identified on chromosomes 2 and 12.

Target	Proteasome Subunit Beta Type 3 (PSMB3)
Origin	Human
Expression	Recombinant
Tested Applications	SDS-PAGE
Host	E. coli
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Form	Liquid
Purity	> 90% (SDS-PAGE)
Purification	Purified by proprietary chromatographic techniques.
Storage	Store at 4 °C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P49720 (UniProt, ExPASy)
UniProt Secondary AC	P31147, Q0P6J7, Q96E27
UniProt Entry Name	PSB3_HUMAN
Gene Symbol	PSMB3
GeneID	5691
OMIM	602176
HGNC	9540
KEGG	hsa:5691
Ensembl	ENSG00000277791
String	9606.ENSP00000483688
Molecular Weight	25.1 kDa
Sequence Fragment	1-205 AA.
Sequence	MGSSHHHHHH SSGLVPRGSH MSIMSYNGGA VMAMKGKNCV AIAADRRFGI QAQMVTTDFQ KIFPMGDRLY IGLAGLATDV QTVAQRLKFR LNLYELKEGR QIKPYTLMSM VANLLYEKRF GPYYTEPVIA GLDPKTFKPF ICSLDLIGCP MVTDDFVVSG TCAEQMYGMC ESLWEPNMDP DHLFETISQA MLNAVDRDAV SGMGVIVHII EKDKITTRTL KARMD
Buffer	20 mM Tris-HCl buffer, pH 8.0, containing 200 mM NaCl, 1 mM DTT and 50% glycerol.
Activity	Not tested
Concentration	0.25 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.

Research Articles on Proteasome Subunit Beta Type 3 (PSMB3)

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