Protein Timeless Homolog (TIMELESS) Antibody

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Catalogue No: abx240110
Price: US$406.00
(Size: 100 µg)

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WB analysis of various lysates, using TIMELESS antibody (1/1000 dilution).
Protein Timeless Homolog (TIMELESS) Antibody

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Protein Timeless Homolog (TIMELESS) Antibody is a Rabbit Polyclonal antibody for the detection of TIMELESS.

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

Target Protein Timeless Homolog (TIMELESS)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen timeless homolog(Drosophila)
Isotype IgG
Form Liquid
Purity ≥ 95% (SDS-PAGE)
Purification Purified by immunogen affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity 12 months.
UniProt Primary AC Q9UNS1 (UniProt, ExPASy)
UniProt Secondary AC B2ZAV0, O94802, Q86VM1, Q8IWH3
UniProt Entry Name TIM_HUMAN
Gene Symbol TIMELESS
GeneID 8914
String 9606.ENSP00000450607
Molecular Weight Observed MW: 140-160 kDa
Buffer PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration 2 mg/ml
Availability Shipped within 5-12 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Protein Timeless Homolog (TIMELESS)
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