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Proteinase 3 Antibody
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Catalogue No: abx011403
Price:
US$427.75
(Size: 100 µl)
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Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Research Articles on Proteinase 3
| Target | Proteinase 3 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human Proteinase 3 expressed in E. coli. |
| Isotype | IgG2b |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P24158 (UniProt, ExPASy) |
| UniProt Entry Name | PRTN3_HUMAN |
| Gene Symbol | PRTN3 |
| GeneID | 5657 |
| OMIM | 177020 |
| HGNC | 9495 |
| KEGG | hsa:5657 |
| Ensembl | ENSG00000196415 |
| String | 9606.ENSP00000234347 |
| Molecular Weight | 28 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |