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Presenilin 1 (PSEN1) Antibody
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Catalogue No: abx001799
Price:
US$348.00
(Size: 60 µl)
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PSEN1 Antibody is a Rabbit Polyclonal antibody against PSEN1. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Research Articles on Presenilin 1 (PSEN1)
| Target | Presenilin 1 (PSEN1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human PSEN1 |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P49768 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R6D3, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0 |
| UniProt Entry Name | PSN1_HUMAN |
| Gene Symbol | PSEN1 |
| GeneID | 5663 |
| NCBI Accession | NP_000012.1 |
| KEGG | hsa:5663 |
| String | 9606.ENSP00000326366 |
| Molecular Weight | Calculated MW: 21 kDa/42 kDa/46 kDa/48 kDa/52 kDa Observed MW: 52 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
