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Proteasome Subunit Alpha Type 7 (PSMA7) Antibody
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Catalogue No: abx034050
Price:
US$326.25
(Size: 80 µl)
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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA7 is a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension.
Research Articles on Proteasome Subunit Alpha Type 7 (PSMA7)
| Target | Proteasome Subunit Alpha Type 7 (PSMA7) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 100-126 amino acids from the Central region of human PSMA7. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | O14818 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R515, Q5JXJ2, Q9BR53, Q9H4K5, Q9UEU8 |
| UniProt Entry Name | PSA7_HUMAN |
| Gene Symbol | PSMA7 |
| KEGG | hsa:5688 |
| String | 9606.ENSP00000359910 |
| Molecular Weight | Calculated MW: 27.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow and Xenopus PSMA7. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |