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Proteasome Subunit Beta Type 8 (PSMB8) Antibody
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Catalogue No: abx006453
Price:
US$217.50
(Size: 20 µl)
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Proteasome Subunit Beta Type 8 (PSMB8) Antibody is a Rabbit Polyclonal Antibody against Proteasome Subunit Beta Type 8 (PSMB8). The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
Research Articles on Proteasome Subunit Beta Type 8 (PSMB8)
| Target | Proteasome Subunit Beta Type 8 (PSMB8) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 163-272 of human PSMB8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P28062 (UniProt, ExPASy) |
| UniProt Secondary AC | B0UZC0, Q29824, Q5JNW6, Q5QNR8, Q96J48 |
| UniProt Entry Name | PSB8_HUMAN |
| Gene Symbol | PSMB8 |
| GeneID | 5696 |
| OMIM | 177046 |
| NCBI Accession | NP_004150.1 NM_004159.4 NP_683720.2 NM_148919.3 |
| KEGG | hsa:5696 |
| String | 9606.ENSP00000364016 |
| Molecular Weight | Calculated MW: 30 kDa Observed MW: 23-28 kDa/23 kDa, 28 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |