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26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody
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Catalogue No: abx028160
Price:
US$326.25
(Size: 80 µl)
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26S Proteasome Regulatory Subunit 7 (PSMC2) Antibody is a Rabbit Poyclonal against 26S Proteasome Regulatory Subunit 7 (PSMC2). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.
Research Articles on 26S Proteasome Regulatory Subunit 7 (PSMC2)
| Target | 26S Proteasome Regulatory Subunit 7 (PSMC2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PSMC2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P35998 (UniProt, ExPASy) |
| UniProt Secondary AC | A4D0Q1, B7Z5E2, Q3LIA5, Q9UDI3 |
| UniProt Entry Name | PRS7_HUMAN |
| Gene Symbol | PSMC2 |
| GeneID | 5701 |
| OMIM | 154365 |
| NCBI Accession | NP_001191382.1 NM_001204453.1 NP_002794.1 NM_002803.3 |
| HGNC | 9548 |
| KEGG | hsa:5701 |
| Ensembl | ENSG00000161057 |
| String | 9606.ENSP00000391211 |
| Molecular Weight | Calculated MW: 48.6 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow and Monkey PSMC2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |