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26S Proteasome Regulatory Subunit 6A (PSMC3) Antibody
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Catalogue No: abx103499
US$319.00
US$223.30
(Size: 100 µl)
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Polyclonal Antibody to 26S Proteasome Regulatory Subunit 6A (PSMC3). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
Research Articles on 26S Proteasome Regulatory Subunit 6A (PSMC3)
| Target | 26S Proteasome Regulatory Subunit 6A (PSMC3) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | PSMC3 (Asn2-Ala439) |
| Form | Liquid |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P17980 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R8V1, Q3B757, Q3B865, Q53HU5, Q6GPG8, Q6IBS1, Q96HD3 |
| UniProt Entry Name | PRS6A_HUMAN |
| Gene Symbol | PSMC3 |
| GeneID | 5702 |
| OMIM | 186852 |
| NCBI Accession | NM_002804 |
| HGNC | 9549 |
| KEGG | hsa:5702 |
| Ensembl | ENSG00000165916 |
| String | 9606.ENSP00000481029 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Note | This product is for research use only. |