26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody (Biotin) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 6B (PSMC4) conjugated to Biotin. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Target |
26S Proteasome Regulatory Subunit 6B (PSMC4) |
Clonality |
Polyclonal |
Reactivity |
Human |
Tested Applications |
ELISA |
Host |
Rabbit |
Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Biotin |
Immunogen |
Recombinant Human 26S protease regulatory subunit 6B protein (112-181AA). |
Isotype |
IgG |
Form |
Liquid |
Purity |
> 95% |
Purification |
Purified by Protein G. |
Storage |
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P43686 (UniProt,
ExPASy)
|
UniProt Secondary AC |
Q96FV5, Q9UBM3, Q9UEX3 |
UniProt Entry Name |
PRS6B_HUMAN |
Gene Symbol |
PSMC4 |
GeneID |
5704
|
OMIM |
602707
|
NCBI Accession |
NP_006494.1
NM_006503.3
NP_694546.1
NM_153001.2
|
HGNC |
9551
|
KEGG |
hsa:5704
|
Ensembl |
ENSG00000013275 |
String |
9606.ENSP00000157812
|
Buffer |
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)