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26S Proteasome Regulatory Subunit 6B (PSMC4) Antibody
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Catalogue No: abx103500
US$319.00
US$223.30
(Size: 100 µl)
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Polyclonal Antibody to 26S Proteasome Regulatory Subunit 6B (PSMC4). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Research Articles on 26S Proteasome Regulatory Subunit 6B (PSMC4)
| Target | 26S Proteasome Regulatory Subunit 6B (PSMC4) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | PSMC4 (Met1-Lys418) |
| Form | Liquid |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P43687 (UniProt, ExPASy) |
| UniProt Secondary AC | Q96FV5, Q9UBM3, Q9UEX4 |
| UniProt Entry Name | PRS6B_HUMAN |
| Gene Symbol | PSMC4 |
| GeneID | 5704 |
| OMIM | 602707 |
| NCBI Accession | NP_006494.1 NM_006503.3 NP_694546.1 NM_153001.2 |
| HGNC | 9551 |
| KEGG | mmu:15372 |
| Ensembl | ENSG00000013275 |
| String | 9606.ENSP00000157812 |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Note | This product is for research use only. |